Compared with mouse thymocytes, mouse ES cells contain increased levels of complete genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 ranges occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic adjustments in H3K4me3 profiles at particular units of genes during ES cell differentiation.
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